مشروع البحث: Relationship between serum sialic acid levels and metabolic variables in libyan type II diabtic ptiens
| dc.contributor.advisor | د.عمر عبدالسلام عقيل | |
| dc.date.accessioned | 2026-06-25T08:20:28Z | |
| dc.date.available | 2026-06-25T08:20:28Z | |
| dc.description | Diabetic disease is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Two major forms of diabetes were identified; type-1 and type-2. Lack of or severe reduction in insulin secretion due to autoimmune or viral destructions of β cells is responsible for type-1 diabetes mellitus, which accounts for 5-10% of diabetic patients. The more prevalent form, type-2 diabetes mellitus, accounts for more than 90% of cases [1]. Type-2 diabetes mellitus usually begins as insulin resistance, a disorder in which the cells do not use insulin properly. [2]. Sialic acid (SA), a generic term for a family of acetylated derivatives of neuraminic acid, is an essential component of glycoprotein's and glycolipids. In patients with type-2 diabetes the levels of sialic acid are increased [3]. Serum sialic acid is a component of cell membranes and elevated levels may indicate excessive cell membrane damage, more specific to the cells of the vascular tissue leading to conditions like retinopathy, nephropathy and neuropathy [4]. Serum sialic acid is newly established potential risk factor for the development of diabetic nephropathy [5]. | |
| dc.description.abstract | BACKGROUND AND OBJECTIVES: Diabetes mellitus is the most common endocrine disorder, the prevalence of which is rising alarmingly in Libya. Serum sialic acid, are found to be increased in a diabetic new patients, diabetes mellitus with complication, cardiovascular diseases, cancer etc. therefore our study aims to understand the association of serum sialic acid levels in diabetic new patients and to assess the correlation of serum sialic acid and HbA1c. High Sialic acid levels in serum of diabetic new patients indicates not only the disease severity but also prognosis, Atherogenic HbA1c and FBS are well known diabetes mellitus risk factors. METHODS: Present study involved 84 participants of which 54 were diagnosed as having diabetic new cases and 30 were age and gender matched healthy controls, who fulfilled inclusion criteria. Blood samples were drawn were collected under aseptic precautions from study subjects. Serum sialic acid, HbA1c, FBS, blood urea, serum creatinine, and lipid profile were estimated in cases and controls. The values were tabulated for cases and controls separately for statistical evaluation. RESULTS: Significant positive correlation and association was found between Sialic acid, HbA1c, FBS, systolic blood pressure and diastolic blood pressure and serum creatinine in type-2 diabetic patients with respect to controls. | |
| dc.identifier | 5980 | |
| dc.identifier.uri | https://dspace.academy.edu.ly/handle/123456789/2360 | |
| dc.subject | sialic acid levels and metabolic variables in libyan | |
| dc.title | Relationship between serum sialic acid levels and metabolic variables in libyan type II diabtic ptiens | |
| dspace.entity.type | Project | |
| project.endDate | 2014 | |
| project.funder.name | الكيمياء | |
| project.investigator | فتحى احمد على الشريف | |
| project.startDate | 2013 |