مشروع البحث: Investigation of the role of the endoplasmic reticulum chaperones GRP78 and GRP94 in the regulation of different hallmarks of cancer in lung adenocarcinoma and breast cancer cells
| dc.contributor.advisor | Dr Costas Demonacos | |
| dc.date.accessioned | 2025-08-19T07:42:07Z | |
| dc.date.available | 2025-08-19T07:42:07Z | |
| dc.description | Results: A549, Beas-2B, and MCF-7 cells treated with endoplasmic reticulum stress inducers overexpress GRP78 and GRP94. PD-L1 and HLA-G were also expressed in these cells under these conditions. GRP94 was upregulated when in cells in which GRP78 had been silenced and vice versa upregulated GRP78 was observed in cells in which GRP94 expression had been silenced. Silencing of GRP78 or GRP94 was negatively associated with PD-L1 cellular levels in A549 and MCF-7 cells treated with Tg, whereas GRP78 or GRP94 positively associated with PD-L1 cellular levels in A549 and MCF-7 | |
| dc.description.abstract | Glucose-regulated protein 78 (GRP78) and Glucose-regulated protein 94 (GRP94) are normally involved in signalling endoplasmic reticulum stress and the unfolded protein response (UPR). High levels of GRP78 and GRP94 protein expression have been identified on the cell surfaces of several cancers, and are involved in promoting tumour survival, progression, immune escape, resistance to anti-cancer treatment and metastasis. | |
| dc.identifier | 664 | |
| dc.identifier.uri | https://dspace.academy.edu.ly/handle/123456789/1718 | |
| dc.subject | endoplasmic reticulum | |
| dc.title | Investigation of the role of the endoplasmic reticulum chaperones GRP78 and GRP94 in the regulation of different hallmarks of cancer in lung adenocarcinoma and breast cancer cells | |
| dspace.entity.type | Project | |
| project.endDate | 2024 | |
| project.funder.name | علم الامراض | |
| project.investigator | نجلاء سلامة | |
| project.startDate | 2023 |