مشروع البحث: Investigation of the role of the endoplasmic reticulum chaperones GRP78 and GRP94 in the regulation of different hallmarks of cancer in lung adenocarcinoma and breast cancer cells
تحميل...
المساهمين
الممولين
رقم التعريف
664
الباحث
نجلاء سلامة
الوصف
Results: A549, Beas-2B, and MCF-7 cells treated
with endoplasmic reticulum stress inducers overexpress GRP78 and GRP94. PD-L1 and HLA-G
were also expressed in these cells under these conditions. GRP94 was upregulated when in
cells in which GRP78 had been silenced and vice versa upregulated GRP78 was observed in
cells in which GRP94 expression had been silenced. Silencing of GRP78 or GRP94 was
negatively associated with PD-L1 cellular levels in A549 and MCF-7 cells treated with Tg,
whereas GRP78 or GRP94 positively associated with PD-L1 cellular levels in A549 and MCF-7
الكلمات الدالة
endoplasmic reticulum