مشروع البحث: Construction of potential drug delivery systems based on polysaccharides
| dc.contributor.advisor | جامعة هدير سفيلد | |
| dc.date.accessioned | 2024-12-12T11:57:17Z | |
| dc.date.available | 2024-12-12T11:57:17Z | |
| dc.description | (prepared in DI water) this may be due to the electrostatic interaction between mucin molecules and phospholipid which is the main component the vesicles. In the final part of the thesis the hydrogel containing chitosan and naturally occurring polyanions and its potential for drug release were studied. Chitosan - polyanion (HGA, LGA, HMP and LMP) hydrogels complexes were successfully prepared (in acetate buffer 0.05M, 4.3 pH) at various ratios (10 %, 30 %, 50 %, 70 % 90 % of Cs) using the ionotropic gelation method. The freeze dried hydrogels were characterized by FT-IR and XRD and the results confirmed the electrostatic interactions between chitosan and polyanions at all ratios and percentage yield of hydrogel δ and εsp results of the supernatant was determined and it was found that the optimum ratios 3:7 and 1:1 of chitosan-pectins and chitosan-alginates respectively. The hydrogels of ideal ratios were studied by determining zeta potential, particles size, water uptake, morphology by scanning electron microscopy for freeze dried hydrogels and optical microscopy analysis for homogenous suspension. In addition, dynamic small deformation oscillatory measurements and adhesion property were studied. Finally, ibuprofen was successfully encapsulated by the chitosan-polyanion hydrogel complexes and the encapsulation efficiency of the formulations was calculated. Finally the drug release behaviour of the formulations was in vitro assessed over the time. The findings demonstrated that HMP and LGA hydrogels displayed the highest percentage of retained ibuprofen following by HGA and LMP. This could be attributed to the fibrous appearance small size of pores which may impedes movements of entrapped molecules. | |
| dc.description.abstract | ABSTRACT Enhancement of the drug efficacy and elimination of the side effects resulting from drug overdoses are an essential aspect in drug therapy. To achieve these demands two general guidelines have been used; producing new drugs with higher selectivity and therefore less side effects and improving controlled/sustained drug delivery agents based on polymers. Thus, the relationship between the active pharmaceutical ingredient and the polymeric system is important in the development of a drug delivery system and several considerations need to be taken in to account, for example the polymer should be biocompatible, biodegradable, and non-toxic and physiochemical properties. Because mucus is the first barrier with which food and drugs can interact with and diffuse through to be absorbed and enter the circulatory system, characterisation mucin is an essential step towards establishing suitable pharmaceutical excipients. Therefore, the aim of the present study was to investigate the potential to construct and study drug delivery systems based on polysaccharides The physicochemical characterisation of extensively degraded pig gastric mucin was studied and revealed that this type of mucin contains: protein, carbohydrate (Fuc, Gal, GalN, GlcN) and sialic acid, which provides the negative charges that becomes progressively stronger with increasing pH. The measurements of viscosity vs. shear rate showed that mucin has a shear thinning behaviour and a relatively low viscosity which is consistent with a high critical overlap concentration (c*), small hydrodynamic size and hence compact structure. The insight in to the compositional, hydrodynamic and viscoelastic properties support the understanding of mucin interactions with polysaccharide based drug delivery systems. | |
| dc.identifier | 349 | |
| dc.identifier.uri | https://dspace.academy.edu.ly/handle/123456789/873 | |
| dc.subject | (prepared in DI water) this may be due to the electrostatic interaction between mucin | |
| dc.title | Construction of potential drug delivery systems based on polysaccharides | |
| dspace.entity.type | Project | |
| project.endDate | 2016 | |
| project.funder.name | كيمياء تحليلية | |
| project.investigator | ATIGA EMHEMED ABODINAR | |
| project.startDate | 2015 |