مشروع البحث: Construction of potential drug delivery systems based on polysaccharides
تحميل...
المساهمين
الممولين
رقم التعريف
349
الباحث
ATIGA EMHEMED ABODINAR
الوصف
(prepared in DI water) this may be due to the electrostatic interaction between mucin
molecules and phospholipid which is the main component the vesicles.
In the final part of the thesis the hydrogel containing chitosan and naturally occurring
polyanions and its potential for drug release were studied. Chitosan - polyanion (HGA, LGA,
HMP and LMP) hydrogels complexes were successfully prepared (in acetate buffer 0.05M,
4.3 pH) at various ratios (10 %, 30 %, 50 %, 70 % 90 % of Cs) using the ionotropic gelation
method. The freeze dried hydrogels were characterized by FT-IR and XRD and the results
confirmed the electrostatic interactions between chitosan and polyanions at all ratios and
percentage yield of hydrogel δ and εsp results of the supernatant was determined and it was
found that the optimum ratios 3:7 and 1:1 of chitosan-pectins and chitosan-alginates
respectively. The hydrogels of ideal ratios were studied by determining zeta potential,
particles size, water uptake, morphology by scanning electron microscopy for freeze dried
hydrogels and optical microscopy analysis for homogenous suspension. In addition, dynamic
small deformation oscillatory measurements and adhesion property were studied. Finally,
ibuprofen was successfully encapsulated by the chitosan-polyanion hydrogel complexes and
the encapsulation efficiency of the formulations was calculated. Finally the drug release
behaviour of the formulations was in vitro assessed over the time. The findings demonstrated
that HMP and LGA hydrogels displayed the highest percentage of retained ibuprofen
following by HGA and LMP. This could be attributed to the fibrous appearance small size of
pores which may impedes movements of entrapped molecules.
الكلمات الدالة
(prepared in DI water) this may be due to the electrostatic interaction between mucin