د.سعيد محمود زميط2026-06-282026-06-28https://dspace.academy.edu.ly/handle/123456789/2388The results showed additional types of overexpressed genes such as; "EGR1, SAMD9 and ORM1". Moreover, EGR1 gene promotes the translocation of AR from the cytoplasm to the nucleus, thus stimulates prostate tumor progression. SAMD9 gene overexpression increases the proliferation and invasiveness of cancer cells, whereas, reduces cell proliferation and motility. ORM1 is antigen receptor “AR” pathway gene, which is best known as an acutephase response marker, has also long been known to be increased in cancer patients and in inflammatory response.Several genes seem to be involved in the development of prostate cancer with disparate expression ratios in different cancer stages. The aim of this study is to detect differential gene expression for prostate cancer using Microarray technology by analysis of Affymetrix Microarray data sets “Human Exon Array 1.0 ST”, and help to improve understanding of the molecular basis of prostate carcinogenesis. Microarray analysis has been used to characterize gene expression profiles of prostate cancer, benign prostatic hyperplasia, and normal prostate tissue data of six samples with different Gleason Scores. The total number of prostate genes of is "22011 genes" while 43 genes are differentially expressed (12 genes up-regulated 31 genes are down-regulated). Genes that observed in the recurrence samples include the SLC (Solute Carriers) family which gene which is “SLC38A11”, The SCL genes provide instructions for making proteins: Solute carriers. However, the membrane proteins are involved in the prognosis of the most common forms of cancer.differential expressed genes for prostate cancer