Prof. Dr. Maher H. HelalProf. Dr. Rafat M. Mohareb2026-06-022026-06-02https://dspace.academy.edu.ly/handle/123456789/2141Pyranopyrazole derivatives are active heterocyclic compounds [1] that have various pharmacological and medicinal applications [2]. Medicinal chemistry has placed a lot of importance on the five- and/or six-membered heterocyclic molecules that include nitrogen (N) and oxygen (O) [3]. Pyranopyrazole synthesis is limited by some factors, including reagent costs, possible environmental hazards, harsh reaction conditions, extended reaction times, time-consuming workup methods, and inadequate yields.A series of novel fused pyrazole derivatives was synthesized through multicomponent reactions of pyrazol-5(4H)-one derivatives with various reagents, affording diverse heterocyclic frameworks. The antiproliferative activity of the synthesized compounds was evaluated against six cancer cell lines using Foretinib as a reference, where several compounds exhibited either broad or selective potent activity. Furthermore, c-Met inhibition and PC-3 cell line assays identified eight compounds with pronounced dual activity, highlighting their potential as promising candidates for anticancer drug development.ACTIVE HETEROCYCLIC COMPOUNDS