Sheffield Hallam University2025-09-022025-09-02https://dspace.academy.edu.ly/handle/123456789/1739Polyacetylene/polyphenols showed great therapeutic potential in leukaemia cell lines, inhibiting proteasomes, modulating HDACs and inducing autophagy and apoptosis. They also acted synergistically with doxorubicin in both wild-type and doxorubicin-resistant cells. Furthermore, their biological activity was enhanced by photoactivation.Background: Leukaemia is a malignant blood disease, the treatment of which is associated with serious side-effects and resistance. Polyphenols and polyacetylenes could provide alternative therapies. They can inhibit proliferation, arrest cell cycle and induce apoptosis in leukaemia cells. However, their therapeutic mechanisms have not been fully elucidated.Leukaemia Cell Lines