مشروع البحث: PARAVENTRICULAR NUCLEUS V1b RECEPTORS MEDIATE INTRANUCLEAR VASOPRESSIN-INDUCED SYMPATHETIC NERVE ACTIVITY IN CONSCIOUS
تحميل...
المساهمين
الممولين
رقم التعريف
343
الباحث
WAFA M. ELWERFALI
الوصف
blockade completely abolished AVP induced changes in both MAP and HR.
Furthermore, we investigated whether peripheral AVP levels increased after
microinjection of AVP into the PVN due to either stimulation of AVP release from
magnocellular neurons into systemic circulation, or AVP leakage from the injection site
to the periphery. In a separate group of rats, we observed that plasma AVP levels 10
minutes after AVP microinjection into the PVN were not significantly different from
baseline levels or from saline-injected controls. Finally, to exclude the possibility of
leakage of centrally injected AVP into the periphery, arterial blood samples were taken
in anesthetized rats before and after PVN microinjection with AVP. Leakage was <
0.3%. These data support the concept that in conscious unrestrained rats under basal
conditions microinjection of AVP into the PVN produces significant increases in mean
الكلمات الدالة
arterial pressure, heart rate and RSNA that are mediated by V1b receptors due to increased sympathetic outflow and not due to AVP release into the periphery