مشروع البحث:
Bacterial Identification and Antibiotic Sensitivity in Diabetic patients with Urinary Tract Infections in Tarhuna City, Libya

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المساهمين
الممولين
رقم التعريف
3-2
الباحث
أسماء امحمد الصغير
المشرفين
منشورات
وحدات تنظيمية
الوصف
UTIs are common among DM patients due to their impaired immune response and metabolic dysfunction. These infections can lead to serious health complications and require accurate evaluation for proper management. Therefore, identifying the causative bacteria and determining their antibiotic sensitivity is crucial to ensure effective treatment. This study aimed to identify the predominant bacterial strains that is responsible for UTIs and to evaluate the AMR patterns of these bacteria in DM patients with UTIs in the Tarhuna city, Libya. Methodology: An analytical cross-sectional study was conducted on 217 DM patients attending Balaj Al-Seha Clinic in Tarhuna City. Urine samples were collected in sterile containers, and a structured questionnaire was administered to each participant. Data collection, and microbiological sampling were carried out over four months, from late December 2024 to early May 2025. Bacterial identification was performed according to standard microbiological protocols. Antibiotic susceptibility testing was carried out using the Kirby–Bauer disc diffusion method. Data were analyzed using SPSS (version 20). Results: The prevalence of significant bacteriuria was 46.1%, with Gram-negative bacteria representing 84% of isolates. Escherichia coli was the predominant uropathogen (58%), followed by Klebsiella pneumoniae (15%). Bacteriuria was significantly associated with marital and economic status, gender, prior antibiotic use, presence of current UTI symptoms, and history of recurrent UTIs. Gram-negative isolates were fully susceptible to imipenem and meropenem (100%), showed high susceptibility to amikacin and piperacillin–tazobactam, moderate susceptibility to amoxicillin–clavulanic acid, cefepime, levofloxacin, and nitrofurantoin, and high resistance to ampicillin, trimethoprim–sulfamethoxazole, ciprofloxacin, and ceftriaxone. Gram-positive bacteria also exhibited complete susceptibility to imipenem and meropenem, high susceptibility to several β-lactams and nitrofurantoin, but marked resistance to ampicillin and chloramphenicol.
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