مشروع البحث:
Finding the variations related to dental and oral health in cancer patients undergoing chemotherapy in western Libya

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المساهمين
الممولين
رقم التعريف
12-1
الباحث
إيناس مفتاح الزوالى
المشرفين
منشورات
وحدات تنظيمية
الوصف
Introduction: Chemotherapy is a cornerstone in the treatment of various cancers but is well-known for its profound side effects on rapidly dividing cells, including those of the oral cavity. This study was conducted to investigate the variations in dental and oral health among cancer patients undergoing chemotherapy, to identify related hematological and biochemical changes, and to provide insights for predicting complications and improving patient care and quality of life. Methodology: A cross-sectional observational study was carried out involving 62 cancer patients undergoing different chemotherapy regimens and 33 healthy controls. Participants completed questionnaires covering oral hygiene habits and existing dental problems. Clinical data, including hemoglobin (Hb), white blood cell count (WBC), platelet count (PLT), neutrophils, C-reactive protein (CRP), calcium, and ferritin levels, were collected before chemotherapy, after three months, and after six months. Descriptive statistics and Pearson’s correlation were used to analyze associations between systemic parameters and oral health outcomes. Results: Prior to chemotherapy, a significant proportion of patients already reported dental problems such as caries and gingivitis. After three months of chemotherapy, the majority developed new or worsening oral complications, including dry mouth (38.7%), taste changes (33.8%), gum bleeding (17.7%), and mouth ulcers (6.9%). Hematological analyses revealed a persistent decrease in hemoglobin, WBC, neutrophils, and platelets over six months, alongside initially elevated and gradually declining CRP and ferritin levels. Significant correlations were identified between hemoglobin and calcium levels, WBC and neutrophils, neutrophils and CRP, and ferritin and platelet count at different time points, demonstrating strong interconnections between systemic health and oral complications. Discussion: The results highlight that chemotherapy-induced immunosuppression, anemia, thrombocytopenia, and systemic inflammation significantly increase the risk of oral complications. Pre-existing dental conditions, combined with reduced salivary flow and mucosal cell damage, exacerbate these risks. The observed correlations underscore the need for ongoing monitoring of hematological and biochemical parameters to predict and manage oral health challenges proactively. Conclusion: The study concludes that cancer patients undergoing chemotherapy are at high risk of developing significant oral health complications due to systemic changes. Early dental assessment, regular monitoring, patient education, and integrated oral health management throughout chemotherapy are strongly recommended to minimize complications and enhance patient quality of life. Keywords: Cancer patients, Chemotherapy, Oral health, Dental complications, Hematological changes, Oral mucositis, Preventive dentistry
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