مشروع البحث: ARPC1B Gene: As a Potential Novel Prostate Cancer Driver
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المساهمين
الممولين
رقم التعريف
834
الباحث
هند زعلوك
الوصف
ARPC1B is involved in many pathways such as
cytoskeleton remodeling via actin; integrin mediated cell adhesion and movement of
cell/subcellular compartments. The purpose of this research was to evaluate the expression levels
of ARPC1B in different prostate cancer cell lines and investigate its potential role in disease
progression. ARPC1B expression was analysed using western blot and qRT-PCR in multiple cell
lines. We found ARPC1B protein and mRNA levels to be upregulated in the PC3 cell line
compared to other cell lines. To validate the role of ARPC1B, siRNA was used to knockdown
ARPC1B in PC3 cells which resulted in significant reduction of cell proliferation as measured
using the MTS assay.
الكلمات الدالة
Prostate Cancer Driver