مشروع البحث: Studies on virulence-critical proteins of enteropathogenic Escherichia coli (EPEC)
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المساهمين
الممولين
رقم التعريف
869
الباحث
عزالدين زايد أحمد مدكور
الوصف
The EspA translocator protein extends the T3SS and is tipped with EspB and EspD which insert into the plasma membrane enabling effector delivery into the host cytoplasm. Two LEE effectors, Tir and EspZ, have virulence-critical functions with both inserted into the plasma membrane and linked, for Tir, as a receptor for EPEC (via Intimin) and, for EspZ, to prevent a cytotoxic response. It is controversial how Tir becomes inserted into membranes and how EspZ prevent cytotoxicity.
الكلمات الدالة
virulence-critical proteins of enteropathogenic