مشروع البحث: Impact of Ascorbic Acid (vitamin C) on periodontal health of diabetic patients in Gharyan city in Northwestern Libya
| dc.contributor.advisor | عمر سعيد مفتاح | |
| dc.date.accessioned | 2026-05-13T08:18:16Z | |
| dc.date.available | 2026-05-13T08:18:16Z | |
| dc.description | Background: Vitamin C (ascorbic acid) plays an essential role in collagen synthesis, immune defence, and antioxidant protection, all of which are important for maintaining periodontal health. Diabetic patients are particularly susceptible to periodontal inflammation due to oxidative stress and impaired wound healing. Aim: This study aimed to evaluate the effect of vitamin C supplementation on periodontal health and glycaemic control among diabetic patients in Gharyan City, Libya, and to assess serum vitamin C levels in relation to periodontal disease severity. The study also sought highlight the antioxidant role of ascorbic acid in reducing periodontal disease. Methods: A crosssectional case–control study was conducted between November 2024 and May 2025, involving 100 participants. The case group included 70 diabetic individuals (aged 10-83 years) receiving hypoglycaemic therapy, while 30 healthy individuals served as controls. Diabetic participants were divided into two subgroups: Group A received 1000 mg/day and Group B received 500 mg/day of effervescent vitamin C for 12 weeks, along with standard periodontal therapy (scaling and root planing). Periodontal indices, including Gingival Index (GI), Plaque Index (PLI), and Clinical Attachment Level (CAL), and glycaemic parameters (RBS, FBS, and HbA1c) were evaluated before and after supplementation. Serum vitamin C levels were also measured. Data were analysed using SPSS version 21, applying paired t-test, independent t-test and Chi-square test, with significance set at p < 0.05. Results: Supplementation with 500 mg/day vitamin C produced a statistically significant improvement in gingival inflammation (reduced GI) but no meaningful effect on plaque accumulation, attachment level, or glycaemic parameters. In contrast, the 1000 mg/day dosage resulted in significant reductions in RBS, FBS, and HbA1c values, along with a greater decrease in GI, indicating improvements in both metabolic and periodontal health. However, neither dosage produced significant changes in plaque accumulation (PLI) or periodontal attachment (CAL). Serum vitamin C levels in diabetic patients were within normal limits. Conclusion: Vitamin C supplementation demonstrated a beneficial effect on gingival health in diabetic individuals, with a dose-dependent improvement observed. The 1000 mg/day dose provided additional benefits in glycaemic regulation, suggesting that higher vitamin C intake may enhance periodontal and metabolic outcomes in diabetic patients. However, vitamin C had limited impact on plaque accumulation and did not improve periodontal attachment levels. | |
| dc.description.abstract | Background: Vitamin C (ascorbic acid) plays an essential role in collagen synthesis, immune defence, and antioxidant protection, all of which are important for maintaining periodontal health. Diabetic patients are particularly susceptible to periodontal inflammation due to oxidative stress and impaired wound healing. Aim: This study aimed to evaluate the effect of vitamin C supplementation on periodontal health and glycaemic control among diabetic patients in Gharyan City, Libya, and to assess serum vitamin C levels in relation to periodontal disease severity. The study also sought highlight the antioxidant role of ascorbic acid in reducing periodontal disease. Methods: A crosssectional case–control study was conducted between November 2024 and May 2025, involving 100 participants. The case group included 70 diabetic individuals (aged 10-83 years) receiving hypoglycaemic therapy, while 30 healthy individuals served as controls. Diabetic participants were divided into two subgroups: Group A received 1000 mg/day and Group B received 500 mg/day of effervescent vitamin C for 12 weeks, along with standard periodontal therapy (scaling and root planing). Periodontal indices, including Gingival Index (GI), Plaque Index (PLI), and Clinical Attachment Level (CAL), and glycaemic parameters (RBS, FBS, and HbA1c) were evaluated before and after supplementation. Serum vitamin C levels were also measured. Data were analysed using SPSS version 21, applying paired t-test, independent t-test and Chi-square test, with significance set at p < 0.05. Results: Supplementation with 500 mg/day vitamin C produced a statistically significant improvement in gingival inflammation (reduced GI) but no meaningful effect on plaque accumulation, attachment level, or glycaemic parameters. In contrast, the 1000 mg/day dosage resulted in significant reductions in RBS, FBS, and HbA1c values, along with a greater decrease in GI, indicating improvements in both metabolic and periodontal health. However, neither dosage produced significant changes in plaque accumulation (PLI) or periodontal attachment (CAL). Serum vitamin C levels in diabetic patients were within normal limits. Conclusion: Vitamin C supplementation demonstrated a beneficial effect on gingival health in diabetic individuals, with a dose-dependent improvement observed. The 1000 mg/day dose provided additional benefits in glycaemic regulation, suggesting that higher vitamin C intake may enhance periodontal and metabolic outcomes in diabetic patients. However, vitamin C had limited impact on plaque accumulation and did not improve periodontal attachment levels. | |
| dc.identifier | 11-1 | |
| dc.identifier.uri | https://dspace.academy.edu.ly/handle/123456789/2052 | |
| dc.subject | علوم حياة | |
| dc.title | Impact of Ascorbic Acid (vitamin C) on periodontal health of diabetic patients in Gharyan city in Northwestern Libya | |
| dspace.entity.type | Project | |
| project.endDate | 2025 | |
| project.funder.name | العلوم الاساسية | |
| project.investigator | منى محمد احمد العيساوي | |
| project.startDate | 2024 |