مشروع البحث: Prevalence of vitamin D deficiency in patients with generalized fatigue and non-specific bone pain
| dc.contributor.advisor | مروان مصطفي دريد | |
| dc.date.accessioned | 2025-03-20T10:00:51Z | |
| dc.date.available | 2025-03-20T10:00:51Z | |
| dc.description | Background: Vitamin D deficiency is a worldwide health problem and has been associated with a number of chronic pain conditions. Scientific evidence indicates that adequate levels of vitamin D have important implications for the management of chronic musculoskeletal pain and fatigue syndromes. Objectives: The purpose of this study is to investigate the prevalence of vitamin D deficiency in patients complaining of fatigue, and nonspecific bone pain, for whom no recognized aetiology, could be identified. Patients and Methods: This cross-sectional study included 300 patients presented with nonspecific musculoskeletal and bone pain at Seoul Hospital in Tripoli. Libya. Vitamin D status was measured and risk factors for vitamin D deficiency were assessed. Results: A total of 300 patients (38 men and 262 women) participated in the study. The mean age ± SEM of all participants was 41.6 ± 0.9 years old. (range 18 - 80 years) The mean of 25(OH) D for male was 17 ± 2.5 whereas female was 14.1± 0.8. Deficiency was more frequent in females, but the difference compared to males was not statistically significant. Approximately 87.7% of the patients are vitamin D deficient deficiency was defined as (< 30 ng/mL). The mean serum 25(OH)D concentration of patients (n 300) was 13.7 ± 10.2 ng/mL. 50.3% had 25(OH)D-levels < 10 ng/mL which is characterized as severe vitamin D deficiency, and 26.7% had 25(OH)D-levels < 20 ng/mL, which is defined as vitamin D deficiency. 9.7% of patients had insufficient of vitamin D, and only 13.3 had sufficient vitamin D status defined as 25(OH)D-levels ≥30 ng/mL. 40 % of studied patients are complaining of fatigue, 29.3 % complaining of back pain and 30.7% complaining of leg pain. Conclusions: Based on our research results, it seems that the majority of patients presented with generalized fatigue and bone pain are suffering from vitamin D deficiency. Risk factors such as failed to be getting sufficient exposure to sunshine, wearing covering clots such as Niqab and hijab by the women, dietary vitamin D intake, vitamin D supplementation, and diabetes appeared to have significant relationship. Whether vitamin D normalization can have positive effects on chronic pain, fatigue and muscle weakness conditions needs further investigation. To that, screening of patients complaining fatigue and muscle weakness for hypovitaminosis D should be standard practice in clinical care | |
| dc.description.abstract | Background: Vitamin D deficiency is a worldwide health problem and has been associated with a number of chronic pain conditions. Scientific evidence indicates that adequate levels of vitamin D have important implications for the management of chronic musculoskeletal pain and fatigue syndromes. Objectives: The purpose of this study is to investigate the prevalence of vitamin D deficiency in patients complaining of fatigue, and nonspecific bone pain, for whom no recognized aetiology, could be identified. Patients and Methods: This cross-sectional study included 300 patients presented with nonspecific musculoskeletal and bone pain at Seoul Hospital in Tripoli. Libya. Vitamin D status was measured and risk factors for vitamin D deficiency were assessed. Results: A total of 300 patients (38 men and 262 women) participated in the study. The mean age ± SEM of all participants was 41.6 ± 0.9 years old. (range 18 - 80 years) The mean of 25(OH) D for male was 17 ± 2.5 whereas female was 14.1± 0.8. Deficiency was more frequent in females, but the difference compared to males was not statistically significant. Approximately 87.7% of the patients are vitamin D deficient deficiency was defined as (< 30 ng/mL). The mean serum 25(OH)D concentration of patients (n 300) was 13.7 ± 10.2 ng/mL. 50.3% had 25(OH)D-levels < 10 ng/mL which is characterized as severe vitamin D deficiency, and 26.7% had 25(OH)D-levels < 20 ng/mL, which is defined as vitamin D deficiency. 9.7% of patients had insufficient of vitamin D, and only 13.3 had sufficient vitamin D status defined as 25(OH)D-levels ≥30 ng/mL. 40 % of studied patients are complaining of fatigue, 29.3 % complaining of back pain and 30.7% complaining of leg pain. Conclusions: Based on our research results, it seems that the majority of patients presented with generalized fatigue and bone pain are suffering from vitamin D deficiency. Risk factors such as failed to be getting sufficient exposure to sunshine, wearing covering clots such as Niqab and hijab by the women, dietary vitamin D intake, vitamin D supplementation, and diabetes appeared to have significant relationship. Whether vitamin D normalization can have positive effects on chronic pain, fatigue and muscle weakness conditions needs further investigation. To that, screening of patients complaining fatigue and muscle weakness for hypovitaminosis D should be standard practice in clinical care | |
| dc.identifier | 7130 | |
| dc.identifier.uri | https://dspace.academy.edu.ly/handle/123456789/1576 | |
| dc.subject | Prevalence of vitamin D deficiency in patients with generalized fatigue and non-specific bone pain | |
| dc.title | Prevalence of vitamin D deficiency in patients with generalized fatigue and non-specific bone pain | |
| dspace.entity.type | Project | |
| project.endDate | 2020 | |
| project.funder.name | الأحياء الدقيقة | |
| project.investigator | منال حسن القريو | |
| project.startDate | 2019 | |
| relation.isOrgUnitOfProject | 2a4bb5ff-48b1-4f80-b63a-91de3ccabeb4 | |
| relation.isOrgUnitOfProject.latestForDiscovery | 2a4bb5ff-48b1-4f80-b63a-91de3ccabeb4 |