مشروع البحث: SYNTHESIS OF BIOLOGICALLY ACTIVE HETEROCYCLIC COMPOUNDS SYNTHESIZED FROM ACTIVE CYANOMETHYLENE REAGENTS AND β-DIKETONES.
| dc.contributor.advisor | Prof. Dr. Maher H. Helal | |
| dc.contributor.advisor | Prof. Dr. Rafat M. Mohareb | |
| dc.date.accessioned | 2026-06-02T10:53:04Z | |
| dc.date.available | 2026-06-02T10:53:04Z | |
| dc.description | Pyranopyrazole derivatives are active heterocyclic compounds [1] that have various pharmacological and medicinal applications [2]. Medicinal chemistry has placed a lot of importance on the five- and/or six-membered heterocyclic molecules that include nitrogen (N) and oxygen (O) [3]. Pyranopyrazole synthesis is limited by some factors, including reagent costs, possible environmental hazards, harsh reaction conditions, extended reaction times, time-consuming workup methods, and inadequate yields. | |
| dc.description.abstract | A series of novel fused pyrazole derivatives was synthesized through multicomponent reactions of pyrazol-5(4H)-one derivatives with various reagents, affording diverse heterocyclic frameworks. The antiproliferative activity of the synthesized compounds was evaluated against six cancer cell lines using Foretinib as a reference, where several compounds exhibited either broad or selective potent activity. Furthermore, c-Met inhibition and PC-3 cell line assays identified eight compounds with pronounced dual activity, highlighting their potential as promising candidates for anticancer drug development. | |
| dc.identifier | 1233 | |
| dc.identifier.uri | https://dspace.academy.edu.ly/handle/123456789/2141 | |
| dc.subject | ACTIVE HETEROCYCLIC COMPOUNDS | |
| dc.title | SYNTHESIS OF BIOLOGICALLY ACTIVE HETEROCYCLIC COMPOUNDS SYNTHESIZED FROM ACTIVE CYANOMETHYLENE REAGENTS AND β-DIKETONES. | |
| dspace.entity.type | Project | |
| project.endDate | 2025 | |
| project.funder.name | كيمياء | |
| project.investigator | SOMIYA MELAD HASSAN SHALOOF | |
| project.startDate | 2024 |