مشروع البحث: Prevalence of High-risk Human Papilloma Virus Types 16 and 18 among Libyan Women in Tripoli, Libya.
تحميل...
المساهمين
الممولين
رقم التعريف
6814
الباحث
هاني رجب الزقوزي
الوصف
Background: The association of HPV and cervical cancer is well established, with scarce in data about prevalence of the most common high risk HPV types among Libyan women.
Aim: To investigate the prevalence of high risk HPV types 16 and 18 among Libyan women, compared to cervical normal cytology and cervical abnormalities in Tripoli, Libya.
Methods: A total of 132 cervical samples were collected from women who sought medical attention at outpatient gynecology clinic of Tripoli Medical Center and other gynecology private clinics in Tripoli region. Cervical cytological status was classified according to Bethesda system 2014. Quantitative polymerase chain reaction (QPCR) was used to facilitate the specific detection of HPV types 16 and/or 18.
Results: Cytological diagnosis showed that 92.4% of women had normal cervical cytology (n=122/132), 7.5% (n=10/132) of them had cervical lesions. The overall prevalence of the most common oncogenic HPV types was 4.5% that only 6 samples (n=6/132) were confirmed of harboring HPV-DNA. With respect to cytological status HPV-DNA was found as 0% of women with normal cervix, and as high as 60% among women with cervical lesions. The high risk HPV 16 was the exclusive type among our positive samples, with no detection of HPV type 18 among all our recruited subjects.
Conclusion: Even though our findings showed low overall prevalence of high risk HPV types among Libyan women, the burden of HPV 16 among women with cervical lesions, highlights the need to raise attention towards expanding research about HPV, adopt measures to prevent cervical cancer by vaccination and national screening program. The introduction of HPV-DNA testing in cervical cancer management will be greatly benefit early stage HPV detection and help prevent cervical lesions progression to cancer.
الكلمات الدالة
Prevalence of High-risk Human Papilloma Virus Types 16 and 18 among Libyan Women in Tripoli, Libya.