مشروع البحث: Assessment of the antimicrobial effect of the silver ions compared to silver nanoparticles
تحميل...
المساهمين
الممولين
رقم التعريف
1350
الباحث
محمد الزروق احمد ابوغوله
الوصف
The precise antibacterial mechanism of action for silver nanoparticles (Ag NPs) is not yet completely understood. A key aspect involves the reported release of silver ions (Ag⁺) from Ag NPs in aqueous environments; these ions are suggested to participate in attacking bacterial cells through multiple pathways, ultimately resulting in cellular damage (N. Hachicho et al., 2014). Research indicates that silver ions interact with the bacterial cell at multiple levels, affecting components such as the cell wall, the cytoplasmic membrane, DNA, and proteins. Proteomic analyses of E. coli have demonstrated a specific adaptive response to silver ions, evidenced by an increased expression level of three outer membrane protein precursors following treatment with nano-silver. This response is triggered to counteract the impact of the ions interacting with the cell wall. Furthermore, it has been reported that both Ag⁺ and Ag NPs significantly influence the cis-trans isomerization of unsaturated fatty acids within the membrane. This effect provides clear evidence that their antibacterial mode of action is linked to the destruction of the membrane's structure and the subsequent breakdown of its essential role as a permeability barrier (N. Hachicho et al., 2014).
الكلمات الدالة
antimicrobial effect of the silver ions