مشروع البحث: The role of tetraspanins in multinucleated giant cell formation induced by Burkholderia thailandensis
| dc.contributor.advisor | Dr .Lynda Partridge | |
| dc.date.accessioned | 2026-04-21T08:26:37Z | |
| dc.date.available | 2026-04-21T08:26:37Z | |
| dc.description | Monocyte/macrophage fusion is associated with chronic inflammation and is thought to be important for immune defence. Monocyte fusion leading to multinucleated giant cell formation (MNGC) has been linked with the pathogenesis of Burkholderia pseudomallei a causative agent of melioidosis disease, a severe invasive disease endemic in south Asia and North Australia. However the mechanism of B.p-induced MNGC formation is unclear. | |
| dc.description.abstract | The tetraspanins are a superfamily of transmembrane proteins with a wide distribution in multicellular organisms. Tetraspanins have been involved in many cellular functions including adhesion, migration and the immune response. Tetraspanins are considered as cell membrane organizers and their function is likely to be due the ability to interact with cell membrane proteins. These interactions lead to them forming a large extended network known as tetraspanin enriched microdomains (TEM) or the tetraspanin web. There is growing evidence for the role of some tetraspanins in various fusion events including sperm-egg fusion, viral-cell fusion and monocyte fusion. | |
| dc.identifier | 945 | |
| dc.identifier.uri | https://dspace.academy.edu.ly/handle/123456789/1953 | |
| dc.subject | The role of tetraspanins in multinucleated giant cell | |
| dc.title | The role of tetraspanins in multinucleated giant cell formation induced by Burkholderia thailandensis | |
| dspace.entity.type | Project | |
| project.endDate | 2016 | |
| project.funder.name | أحياء دقيقة | |
| project.investigator | عتيقة محمد السنوسي | |
| project.startDate | 2015 |