مشروع البحث: Variation in Haematological Parameters and Liver Biochemical Tests in Patients infected with Chronic HCV and Hepatitis B in Libya
تحميل...
المساهمين
الممولين
رقم التعريف
7039
الباحث
كمال الهادي مولود الشيباني
الوصف
Chronic viral hepatitis is an important health problem in the world, where hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are the main causes of liver insufficiency.
This study was a comparative case control study. It aimed to assess the variations in hematological parameters and liver biochemical test in patients infected with HCV and HBV viruses in the western region of Libya.
A total of 120 blood samples from patients with chronic viral hepatitis were collected; 60 with HCV and 60 with HBV infection. Twenty healthy individuals were included as a control group. Out of the 60 patients with HBV, 43 (36%) were males and 17 (14%) were females, while 38 (32%) patients with HCV were males and 22 (18%) were females. The mean age for HBV patients was 36.9 ± 15.8 years and for HCV patients the mean was 39.9 ±14.2 year.
The results of the liver biochemical tests showed no significant difference between HCV and HBV patients. Though the mean concentration and count of hematological profile (total white blood cell count and hemoglobin estimation of infected patients), showed low significant difference in HCV patients (WBC 5.98 ± 0.29 cell/mm3, Hb 12.96 ± 0.20g/dl) as compared with control group (WBC 7.48 ± 0.42 cell /mm3, Hb 13.75 ± 0.30g/dl) with P value 0.027 and 0.005, respectively. However, there was no significant difference between HBV patients and control group regarding hemoglobin concentration.
Additionally, platelets count revealed low significant difference in HCV and HBV patients (193.2 ± 9.73 ×10(9)/L) (177.2 ± 6.57×10(9)/L), respectively, in comparison with control group (242.0 ± 13.53×10(9)/L, P value (0.001)). HCV and HBV patients showed a highly significant difference regarding liver biochemical tests. The mean concentration of Total Bilirubin, Direct Bilirubin, Indirect Bilirubin and ALT enzyme in HCV and HBV patients (0.74 ±0.054, 0.26±0.24,0.48 ±0.033 mg/L and 23.45±1.18 u/L), (0.81±0.049, 0.30±0.024, 0.51±0.029 mg/dl and 26.20±1.38 u/L), (0.55 ± 0.039, 0.18 ± 0.17, 0.37 ± 0.026 mg/dl and 15.80 ± 1.54 u/L) when compared with the control group with P values (0.030, 0.036, 0.049 and 0.000), respectively.
In conclusion, there were significant difference in hematological profile. Additionally, liver function tests of patients infected with chronic HCV and HBV were also of significant importance, when compared with control group
الكلمات الدالة
Variation in Haematological Parameters and Liver Biochemical Tests in Patients infected with Chronic HCV and Hepatitis B in Libya