مشروع البحث: Study the Effect Of Antioxidants Garlict And Green Tea Against Liver Growth Tnduced With Ciprofibrate
تحميل...
المساهمين
الممولين
رقم التعريف
7167
الباحث
تهاني سالم الجيلاني
الوصف
The liver is one of the main organs that have the main function in the detoxification and disposal of the body from the toxins. It is exposing to many toxic substances daily either through the environment or from many other sources such the preservatives or drugs which increase the risk of liver growth. This study addressed to one of the commonly used drugs called ciprofibrate (Cipro). Ciprofibrate is one of peroxisome proliferators' chemical families that stimulate hepatic cells then uncontrollably divided, causing liver growth..
Two antioxidants (garlic and green tea) are used in this study to investigate the effect of these substances on the biochemical parameters of liver enzymes and tissue changes in the Fisher rat. In the current study nine groups of 6 males, rats were used (Control group, Oil, Garlic, Ciprofibrate 50 and 100mg, Cipro 50mg with garlic, Cipro 100mg with garlic, Cipro 100mg with green tea and garlic with Cipro 100mg). The rats have been treated daily orally (gavages) for 21 days. At the last day of the experiment the animals were killed then blood samples and parts from the liver were collected. Liver function was examined for the enzyme activities; serum Alanine Aminotransferase(ALT), Aspartate Aminotransferase(AST), Alkaline phosphates(ALP), serum total and direct bilirubin. Histopathological investigation was conducted for the liver tissues of all groups. The current results have achieved a number of results can be summarized as follows: There was a significant increase of liver enzymes in all groups that treated with either 50 or 100 mg ciprofibrate. In terms of Histopathological changes; there were histological changes in central vein area and portal zones, revealed necrosis or cell death. The current study has used antioxidant substances to reduce the risk of the PPs (ciprofibrate), which might be carcinogenic by a long term of treatment. The antioxidants were used as therapeutic or preventive substances agents to inhibition of the liver cell proliferation. The results showed a positive effect of both antioxidants against liver growth originates.