مشروع البحث: Innovative approaches to study basophil function in inflammation
| dc.contributor.advisor | Professor Joachim Lundahl | |
| dc.contributor.advisor | Associated professor Aman Russom | |
| dc.contributor.advisor | Professor Ola Winqvist | |
| dc.contributor.advisor | Associated professor Anna Nopp | |
| dc.date.accessioned | 2024-12-12T08:09:32Z | |
| dc.date.available | 2024-12-12T08:09:32Z | |
| dc.description | Basophils are circulating granulocytes. They are very rare and represent less than 1% of peripheral blood leukocytes. Basophils connect the innate and adaptive immune responses by the secretion of a variety of immune-mediators involved in the pathogenesis of many inflammatory diseases mainly allergic reactions and autoimmune diseases. For many years it was difficult to study basophil function due to their rareness in peripheral blood which resulted in scant yields and purity when isolated. This thesis focuses on studies of the basophil function in two inflammation-driven diseases: chronic kidney disease (CKD) and allergy. The investigations have been done using newly developed microfluidic-based lab-on-chip technology and conventional immunological methods. In paper I, we investigated the impact of blood-membrane interaction on circulating basophils and neutrophils in hemodialysis patients (stage 5D), using high-flux and low-flux dialyzers. Passage through the low-flux dialyzer, as opposed to high-flux, induced a significant upregulation of CD63 | |
| dc.description.abstract | Basophils are circulating granulocytes. They are very rare and represent less than 1% of peripheral blood leukocytes. Basophils connect the innate and adaptive immune responses by the secretion of a variety of immune-mediators involved in the pathogenesis of many inflammatory diseases mainly allergic reactions and autoimmune diseases. For many years it was difficult to study basophil function due to their rareness in peripheral blood which resulted in scant yields and purity when isolated. This thesis focuses on studies of the basophil function in two inflammation-driven diseases: chronic kidney disease (CKD) and allergy. The investigations have been done using newly developed microfluidic-based lab-on-chip technology and conventional immunological methods. In paper I, we investigated the impact of blood-membrane interaction on circulating basophils and neutrophils in hemodialysis patients (stage 5D), using high-flux and low-flux dialyzers. Passage through the low-flux dialyzer, as opposed to high-flux, induced a significant upregulation of CD63 | |
| dc.identifier | 296 | |
| dc.identifier.uri | https://dspace.academy.edu.ly/handle/123456789/856 | |
| dc.subject | Innovative approaches to study basophil function in inflammation | |
| dc.title | Innovative approaches to study basophil function in inflammation | |
| dspace.entity.type | Project | |
| project.endDate | 2017 | |
| project.funder.name | طب | |
| project.investigator | زينب محمد الجدي | |
| project.startDate | 2016 |