مشروع البحث:
Molecular Mechanisms of Action of Polyphenols and Polyacetylenes in Leukaemia Cell Lines

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dc.contributor.advisorSheffield Hallam University
dc.date.accessioned2025-09-02T08:25:14Z
dc.date.available2025-09-02T08:25:14Z
dc.descriptionPolyacetylene/polyphenols showed great therapeutic potential in leukaemia cell lines, inhibiting proteasomes, modulating HDACs and inducing autophagy and apoptosis. They also acted synergistically with doxorubicin in both wild-type and doxorubicin-resistant cells. Furthermore, their biological activity was enhanced by photoactivation.
dc.description.abstractBackground: Leukaemia is a malignant blood disease, the treatment of which is associated with serious side-effects and resistance. Polyphenols and polyacetylenes could provide alternative therapies. They can inhibit proliferation, arrest cell cycle and induce apoptosis in leukaemia cells. However, their therapeutic mechanisms have not been fully elucidated.
dc.identifier705
dc.identifier.urihttps://dspace.academy.edu.ly/handle/123456789/1739
dc.subjectLeukaemia Cell Lines
dc.titleMolecular Mechanisms of Action of Polyphenols and Polyacetylenes in Leukaemia Cell Lines
dspace.entity.typeProject
project.endDate2023
project.funder.nameالتقنية الطبية
project.investigatorحمزة عبد السلام الاسود
project.startDate2022
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