مشروع البحث:
دراسة مؤشر كتلة الجسم و الكا لبروتكتين البرازي لدى مرضى التهاب الامعاء في مدينة الخمس الليبية

صفحة عناصر بسيطة
dc.contributor.advisorأ.د خيري الهادي لغويل
dc.date.accessioned2026-05-20T09:28:03Z
dc.date.available2026-05-20T09:28:03Z
dc.descriptionBackground: Inflammatory bowel disease (IBD), comprising Crohn’s disease and ulcerative colitis, is a chronic immune-mediated inflammatory disorder of the gastrointestinal tract characterized by a relapsing–remitting course and significant systemic and nutritional consequences. Although traditionally more prevalent in high-income countries, the incidence of IBD is rising in low- and middle-income regions, including North Africa. In Libya, diagnostic delays remain common due to limited access to endoscopic facilities, high procedural costs, and healthcare infrastructure constraints, particularly outside tertiary centers. These challenges highlight the need for reliable, non-invasive, and economically feasible biomarkers to support early diagnosis and disease monitoring. Fecal calprotectin (FC) is a validated marker of intestinal inflammation, while body mass index (BMI) reflects nutritional and metabolic status; however, data examining their interrelationship in Libyan or North African populations are scarce. Objectives: This study aimed to investigate the association between body mass index and fecal calprotectin levels in patients evaluated for IBD in Al-Khums City, Libya. Secondary objectives included assessing the diagnostic accuracy of fecal calprotectin in differentiating IBD from non-IBD conditions and evaluating its cost-effectiveness compared with invasive diagnostic procedures. Methods: A descriptive, analytical, cross-sectional study was conducted involving 126 participants with complete demographic, clinical, anthropometric, and laboratory data, selected from an initial cohort of 188 screened individuals. Participants were categorized into IBD and non-IBD groups based on clinical assessment, endoscopic findings, and histopathological confirmation where available. Anthropometric measurements (weight, height, BMI) and laboratory markers—including fecal calprotectin, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), hemoglobin, and white blood cell count—were analyzed using IBM SPSS Statistics. Comparative analyses, correlation testing, and receiver operating characteristic (ROC) curve analysis were performed to assess associations and diagnostic performance.
dc.description.abstractBackground: Inflammatory bowel disease (IBD), comprising Crohn’s disease and ulcerative colitis, is a chronic immune-mediated inflammatory disorder of the gastrointestinal tract characterized by a relapsing–remitting course and significant systemic and nutritional consequences. Although traditionally more prevalent in high-income countries, the incidence of IBD is rising in low- and middle-income regions, including North Africa. In Libya, diagnostic delays remain common due to limited access to endoscopic facilities, high procedural costs, and healthcare infrastructure constraints, particularly outside tertiary centers. These challenges highlight the need for reliable, non-invasive, and economically feasible biomarkers to support early diagnosis and disease monitoring. Fecal calprotectin (FC) is a validated marker of intestinal inflammation, while body mass index (BMI) reflects nutritional and metabolic status; however, data examining their interrelationship in Libyan or North African populations are scarce. Objectives: This study aimed to investigate the association between body mass index and fecal calprotectin levels in patients evaluated for IBD in Al-Khums City, Libya. Secondary objectives included assessing the diagnostic accuracy of fecal calprotectin in differentiating IBD from non-IBD conditions and evaluating its cost-effectiveness compared with invasive diagnostic procedures. Methods: A descriptive, analytical, cross-sectional study was conducted involving 126 participants with complete demographic, clinical, anthropometric, and laboratory data, selected from an initial cohort of 188 screened individuals. Participants were categorized into IBD and non-IBD groups based on clinical assessment, endoscopic findings, and histopathological confirmation where available. Anthropometric measurements (weight, height, BMI) and laboratory markers—including fecal calprotectin, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), hemoglobin, and white blood cell count—were analyzed using IBM SPSS Statistics. Comparative analyses, correlation testing, and receiver operating characteristic (ROC) curve analysis were performed to assess associations and diagnostic performance.
dc.identifier3-12
dc.identifier.urihttps://dspace.academy.edu.ly/handle/123456789/2090
dc.subjectعلوم حياة
dc.titleدراسة مؤشر كتلة الجسم و الكا لبروتكتين البرازي لدى مرضى التهاب الامعاء في مدينة الخمس الليبية
dspace.entity.typeProject
project.endDate2026
project.funder.nameعلوم اساسية
project.investigatorفارس احمد محمد أبو راس
project.startDate2025
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3-12Study of Body Mass Index and Fecal Calprotectin of Patients with Inflammatory Bowel Disease in Li.pdf
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