مشروع البحث: Correlation Between Dental Diseases and Fungal Sinusitis
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المساهمين
الممولين
رقم التعريف
16-1
الباحث
خديجة عبدالحميد مصباح
الوصف
With the increasing of dental diseases associated with fungal infection, this study investigated the correlation between dental diseases and fungal sinusitis in Gharyan municipality. From each of the 120 patients, two distinct specimens were collected: a nasopharyngeal specimen and an oral specimen from the tooth surfaces and subgingival region, were cultured on Sabouraud agar with cycloheximide. The results showed that seventy-two oral and forty-eight nasal samples were positive for fungi. Candida albicans dominated oral isolates (84.1%), while nasal isolates were rare (two cases), including C. albicans and C. krusei. Hyphomycetes species such as Penicillium chrysogenum (25.86%), Cladosporium sphaerospermum (15.52%), and Alternaria tenuissima (15.51%) were commonly detected, reflecting a broad environmental fungal presence. Most demographic and health variables were not significantly associated with colonization, except oral hygiene (linked to nasal hyphomycetes, p=0.017) and smoking (linked to oral Candida, p=0.047). Amphotericin B showed the highest efficacy against oral Candida, while Posaconazole and Itraconazole were most effective against hyphomycetes. Three cases had matching oral and nasal isolates (Penicillium chrysogenum, Paecilomyces lilacinus, Candida albicans). It is concluded that there is a strong link between oral and nasal fungal elements, indicating possible co-colonization or microbial migration.
Keywords: Dental diseases, fungal sinusitis, Candida albicans, Hyphomycetes, antifungal susceptibility.
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